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	Provedor de dados BJMBR (2) Autor Souza,A.L.S. (2) Teixeira,M.M. (2) Barcelos,L.S. (1) Lana-Peixoto,M.A. (1) Machado,C.R. (1) Machado,P.P. (1) Mariano,F.S. (1) Moreira,M.A. (1) Roffê,E. (1) Romanha,A.J. (1) Silva,J.S. (1) Tanowitz,H.B. (1) Teixeira,A.L. (1) Mais... Palavra-chave CCL2 (1) CXCL10 (1) Chemokines (1) Endothelin (1) Inflammation (1) Leukocyte recruitment (1) Multiple sclerosis (1) Myocarditis (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis BJMBR Moreira,M.A.; Souza,A.L.S.; Lana-Peixoto,M.A.; Teixeira,M.M.; Teixeira,A.L.. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. They are divided into subfamilies on the basis of the location of conserved cysteine residues. We determined the levels of some CC and CXC chemokines in the cerebrospinal fluid (CSF) of 23 relapsing-remitting MS patients under interferon-ß-1a therapy and 16 control subjects using ELISA. MS patients were categorized as having active or stable disease. CXCL10 was significantly... Tipo: Info:eu-repo/semantics/article Palavras-chave: CXCL10; CCL2; Inflammation; Multiple sclerosis; Leukocyte recruitment. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400003 Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice BJMBR Roffê,E.; Souza,A.L.S.; Machado,P.P.; Barcelos,L.S.; Romanha,A.J.; Mariano,F.S.; Silva,J.S.; Machado,C.R.; Tanowitz,H.B.; Teixeira,M.M.. Chagas' disease, caused by the protozoan Trypanosoma cruzi, is a major cause of cardiovascular disability in countries where it is endemic. Damage to the heart microvasculature has been proposed to be an important factor in the pathogenesis of heart dysfunction. Endothelin-1 (ET-1) is a potent vasoconstrictor and exerts its effects via specific ET A and ET B receptors. A few studies have suggested a role for ET-1 and its receptors in the pathogenesis of Chagas' disease. We investigated the effects of treatment with bosentan, an ET A/ET B receptor antagonist, on the course of T. cruzi infection (Y strain) in C57Bl/6 mice. Treatment with bosentan (100 mg kg-1 day-1) was given per os starting day 0 after infection until sacrifice. Bosentan significantly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Endothelin; Myocarditis; Chemokines. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300015 Registros recuperados: 2 Primeira ... 1 ... Última

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